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IVAM Microtechnology Network
The effectiveness of pharmaceuticals, the efficiency of catalysts, and the performance of printing inks depend significantly on the size of the nanoparticles they contain. However, there has been a lack of methods to monitor particle size distribution during the milling process. In the EU-funded project PAT4Nano, a consortium of industry and research partners has explored practical approaches for inline measurements over the past four years. The Fraunhofer Institute for Laser Technology ILT in Aachen has developed a promising laser-based method that could soon fill this gap.
The ILT has developed a novel method for inline measurement of particle size distribution during the milling process. This method is crucial for industries such as pharmaceuticals, catalysts, and printing inks, where nanoparticle size is vital for product quality. For example, the dissolution rate and sustained effect of drug particles in the body depend on their size. A newly developed inline probe with a rotating paddle wheel allows precise sampling and measurement without interrupting the process. The required inline measurement technology combines a laser scattering method with real-time mathematical algorithms.
Measuring particles under 100 nanometers poses a significant challenge, as conventional microscopic imaging methods often reach their limits. The ILT team has addressed this challenge by combining laser scattering techniques with real-time mathematical algorithms, significantly improving measurement precision. Dynamic light scattering (DLS) and advanced optical systems are used to overcome issues such as multiple scattering and high particle concentrations.
The ILT's novel measurement technique shows great potential for industrial applications. The institute is currently working on further refining and commercializing the technology. Successful integration of this method could lead to significant improvements in process monitoring and product consistency across various sectors.
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